中华脑科疾病与康复杂志(电子版) 2016年6月,6卷3期

综述

视神经脊髓炎与血脑屏障

张静茹 董慧芳 张美妮

030001 太原,山西医科大学第一医院神经内科
张美妮,Email:meinizhang@611hotmail.com

摘要:视神经脊髓炎(NMO)是一种主要累及视神经和脊髓的炎性脱髓鞘疾病,既往认为是多发性硬化的特殊亚型,随着NMO患者血清中特异性抗体NMO-IgG及其作用靶点的发现,NMO成为一个独立的疾病实体而不同于多发性硬化。近年的研究显示,NMO-IgG产生于血液循环,只有在血脑屏障破坏的前提下才能进入中枢神经系统发挥其致病作用,可见血脑屏障的破坏在NMO疾病的发生发展过程中具有重要意义。

关键词:视神经脊髓炎; 血脑屏障

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(编辑:杨智华 收稿日期:2016-04-22)